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Clinical studies show that roughly 70% of users report improved tolerance by week 4, and the majority experience substantial symptom relief by weeks 68

When using an antidepressant to treat neuropathic pain, minimizing the use of venlafaxine and TCAs and instead using duloxetine should be considered

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Rarely, meningeal melanocytes may undergo malignant transformation into meningeal melanocytosis and melanomatosis and diffusely disseminate throughout the meninges [18]